HLA A*0201 allele accounts for DQ2/DQ8 negative genome screening in celiac disease patients

Abstract

Listen

Translate article

Background: HLA class II alleles DQA1*0501/DQB1*0201 are the antigen presenting cells surface receptors for deamidated toxic gliadin fragments. Despite that their presence is considered necessary for celiac disease (CD) pathogenesis, these two alleles account for only 90-95% of the genomic pattern of CD HLA class II DQ2/DQ8 haplotypes. It has been recently reported that HLA DQ2 haplotype can be coded by the previously undescribed A*0201 allele.