Abstract
Short guanine-rich sequences have a tendency to form quadruplexes that are stabilized by G-quartets with specific cation coordination. Quadruplex structures are part of telomeres at the ends of chromosomes and play an important role in the regulation of gene expression. In addition, there is a strong interest in the therapeutic and biotechnological potential of quadruplex oligonucleotides. The HIV-integrase aptamer, d(GGGT)4, demonstrates unusually favorable van’t Hoff thermodynamics, and based on NMR studies the aptamer was proposed to fold into an antiparallel quadruplex structure.
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