Abstract
BackgroundUnderstanding about who acquires new HIV infection and the determinants of why some persons get infected and others do not is fundamental to controlling HIV in the population. We assess HIV incidence and its associations in the population of a high HIV burden district in Andhra Pradesh state in southern India by a population-based longitudinal cohort study.MethodsWe re-surveyed a population-based cohort of 12,617 adults in Guntur district of Andhra Pradesh for which we had reported a baseline HIV prevalence of 1.72% (rural 1.64%, urban 1.89%) among the 15–49 years age group in 2004–2005. We conducted interviews to assess risk behaviour and performed HIV testing again in 2010–2011. We assessed the rate of new HIV infection and its associations using multiple logistic regression.ResultsThe participation rate in the follow-up was 74.9% and 63.9% of the baseline rural and urban samples, respectively. Over a mean follow-up of 5.63 years, the incidence of HIV was 1.26 per 1000 person-years (95% CI 0.83-1.69), after adjusting for slight compositional bias in the follow-up sample. The incidence per 1000 person-years was higher among rural men (1.68) than urban men (0.85), and among rural women (1.28) than urban women (0.54). The strongest association with incidence was a HIV positive spouse in the baseline for both men (odds ratio 266, 95% CI 62–1137) and women (odds ratio 28, 95% CI 9–88). Among men the other significant associations with HIV incidence were frequent use of condom for sex over the past 6 months, non-circumcision, more than one lifetime woman sex partner or ever visited sex worker, and transport-related occupation; for women the other significant associations were having had HIV testing other than antenatal check-up, previously married but currently not, and tobacco use.ConclusionThese first population-based cohort incidence data from India suggest that rural areas of high HIV burden states would need more attention to prevent new HIV infections, and that spouses of HIV positive persons and some other risk groups need to be targeted more effectively by HIV prevention programmes.
Highlights
Understanding about who acquires new HIV infection and the determinants of why some persons get infected and others do not is fundamental to controlling HIV in the population
While the prevalence of HIV in the population has been better understood in India over the past few years through population-based studies [18,19,20,21], so far there have been no data reported on the rate of new HIV infections, i.e. incidence of HIV, in the population from a longitudinally followed-up population-based cohort
In this paper we report HIV incidence from such a cohort in a high HIV burden district in the south Indian state of Andhra Pradesh followed up for over 5 years, and the factors associated with HIV incidence
Summary
Understanding about who acquires new HIV infection and the determinants of why some persons get infected and others do not is fundamental to controlling HIV in the population. We assess HIV incidence and its associations in the population of a high HIV burden district in Andhra Pradesh state in southern India by a population-based longitudinal cohort study. While the prevalence of HIV in the population has been better understood in India over the past few years through population-based studies [18,19,20,21], so far there have been no data reported on the rate of new HIV infections, i.e. incidence of HIV, in the population from a longitudinally followed-up population-based cohort. In this paper we report HIV incidence from such a cohort in a high HIV burden district in the south Indian state of Andhra Pradesh followed up for over 5 years, and the factors associated with HIV incidence
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