Abstract
HIV/AIDS symptoms, treatment efficacy and type of treatments differ from one region/country to another. In this article, we discuss and analyze American Midwest patients HIV/AIDS laboratory data. A total of 9,392 patient’s visits for 2,588 patients have been considered. The efficacy of different treatments, in terms of reducing the Ribonucleic acid (RNA), and/or increasing the CD4 counts, has been analyzed. We provide data summary graphs that help to identify important patterns embedded in patient’s reactions to different therapies. We provide statistical evidence regarding treatment tolerance (in terms of the number of consecutive times a given treatment can be used on a considered patient) and most effective treatments (in terms of the rate of change in CD4 and RNA levels). We avoided using genetic sequences, to help understand the treatment efficacy, based solely on basic laboratory tests (CD4 count and RNA levels). We believe that since genetic analysis cannot be easily obtained in resource-limited countries, it is important to investigate if basic laboratory data (when collected in large quantities) will be sufficient to determine the most effective treatments. We show that, before 2004, the percentage of CD4 count>350 kept improving to rise from about 51% on 2000, to about 55% in 2004. During the same period of time, the percentage of undetectable RNA level declined from about 65% to about 52%. We also show that both healthy CD4 count of >350 cells/μl and undetectable RNA level ( 350 going up from about 55% in 2004 to about 65% in 2007. We provide statistical analyses and efficacy evaluation, related to the most significant treatments throughout the years 2000-2008. All data and analysis tools are provided on our Midwest HIV/AIDs web portal (http://hivdatamining.com).
Highlights
In 2011, the National Institutes of Health published guidelines for the Use of Antiretroviral Agents in HIV-1-Infected adults and Adolescents [1]
Only 35% of the patients taking “Epivire, Sustiva, Viread” were able to use the treatment for more than three consecutive prescriptions. This clearly indicates less severe side effect associated with Trizivir, compared with “Epivire, Sustiva, Viread”
Data mining analysis performed on 9,392 HIV/AIDS patients visits shows that, before 2004, treatments aimed at improving the CD4 count, ignoring the fact that the Ribonucleic acid (RNA) level kept inclining
Summary
In 2011, the National Institutes of Health published guidelines for the Use of Antiretroviral Agents in HIV-1-Infected adults and Adolescents [1]. We show that the treatment combination Kaletra+Truvada, on average, reduced the RNA level by about 600 viral/day (when used as a first line treatment).
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