Abstract
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class, bearing an additional acid group or a propenoic acid moiety at the C-5 position of the quinoline have been synthesized. Key steps included Heck reaction and palladium catalyzed carbonylation reaction of 5-haloquinaldine derivatives. These compounds exhibited reinforced anti-integrase potency and significant antiviral activities.
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