Abstract
The nucleocapsid protein of HIV-1 (NC) is a multi-functional protein necessary for viral replication. NC binds nucleic acids with high affinity and acts as a chaperone during reverse transcription. Recent studies have demonstrated reverse transcription occurs inside the fully intact capsid and that the timing of reverse transcription and uncoating are correlated. How exactly a nearly 10 kbp viral dsDNA genome is stably contained within a narrow capsid with diameter approximately equal to the persistence length of dsDNA, and NC's role in this process, are not well understood.
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