Abstract
Abstract The serologic surveys reported in this paper present confirmatory evidence of the importance of histoplasmosis as a problem in tuberculosis sanatoriums in the United States. Employing the Histoplasmin complement fixation test 2 per cent of 9,774 patients were found to be positive, while employing the yeast phase antigen 6 per cent of 5,311 patients were found to be positive. The positives tended to occur in sanatoriums from Kansas to Maryland, with the higher prevalence in the sanatoriums in the high histoplasmosis belt. There is every evidence that the employment of additional antigens in the serologic tests would increase the yield of positive reactors. Difficuties inherent in the serologic tests are discussed and some further study of the yeast phase antigen is indicated. Cross reactions with other fungus antigens, such as Coccidioidin and Blastomycin, are reported and discussed.
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