Abstract
BackgroundThe aim of our study was to evaluate the histological characteristics and prognosis of gastric cancer.MethodsClinicopathlogical variables of 932 patients with gastric carcinoma admitted to the Department of Surgical Oncology at the First Hospital of China Medical University were analyzed retrospectively. Different histological characteristics of gastric cancer were summarized and assigned score according to the malignancy defined by WHO classification, the scores were stratified into 4 stage, the prognosis of different stages were analyzed by Kaplan-Meier analysis and cox regression.ResultsAmong the 932 patients, 246 (26.39%) had mixed histology type of gastric cancer. Compared to the pure histological type, mixed histological type of gastric cancer was significant associated with tumor size, lymph node metastasis and depth of invasion (all P < 0.05). The 5-year survival rates of advanced and early gastric cancer patients with mixed type were 40.8% and 83.5% respectively, which were lower than those with pure type (50.0% and 95.8%, P < 0.01). Statistically significant difference with stratification of early and advanced stage could be observed between patients with the histological grading score. The data showed that the histological score could be the independent factor of prognosis.ConclusionsThe histological score is an independent factor of gastric cancer, it exerts an excellent ability to classify survival of patients with gastric carcinoma. It also provides a new strategy and parameter for evaluating the biological behavior and prognosis of gastric cancer.
Highlights
The aim of our study was to evaluate the histological characteristics and prognosis of gastric cancer
Compared to the pure histological type, mixed histological type gastric cancer was significant associated with tumor size, lymph node metastasis and depth of invasion
The 5-year survival rates of advanced and early gastric cancer patients with mixed form were 40.8% and 83.5% respectively, which were lower than those with pure form (50.0% and 95.8%, P < 0.01) ( Figure 2)
Summary
The aim of our study was to evaluate the histological characteristics and prognosis of gastric cancer. Except for stage of the tumor, there have not been any criteria using histopathological tumor-related factors to determine the outcome of the patients with gastric carcinoma. Histopathological type is an important prognosis factor, it is to determine the extent of surgical resection and. The coexistence of different histological types of gastric cancer determines the the complex characteristics of clinical behavior and prognosis, the mixed histological type accounted for over 25% of all gastric cancer [9,10]. Since major diagnostic principles are used, the highly heterogeneous histological features of gastric cancer were ignored, tumor biological behavior and prognostic value of minor histological type were coved up [11].
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