Histopathological Types of Ovarian Cancer in Different Age Group of Patients; A Single Institution Experience

Abstract

Objective: To see the relationship between age and histological types among patients presenting with ovarian cancer at tertiary care hospital, of Karachi Pakistan. Study Design: Cross-sectional study. Place and Duration of study: Department of medical oncology, Jinnah Postgraduate Medical Centre, Karachi Pakistan from Mar 2019 to May 2020. Methodology: Three fifty women presenting with confirmed diagnosis of ovarian carcinoma were included irrespective of their age. The information regarding socio-demographics and family history were noted on pre-designed proforma. Pathology reports were obtained from all the patients and information regarding age, stage and histological type were noted. World Health Organization classification was used to classify the histological type of tumours. All data was entered and analyzed using SPSS version 23. Results: The mean age of the study sample was estimated as 44.27±12.7 years ranging from 14-92 years. According to histological type, most of the females had surface epithelial tumors 307(87.71%), followed by sex cord-stromal tumors 20(5.7%) and germ cell tumors tumors 19(5.43%) respectively. The statistically significant difference was observed between age and histological types and subtypes of ovarian cancer (p<0.05). Conclusion: It is concluded that age is an important factor in determining risk of developing different types of ovarian cancers. Serous type of epithelial ovarian cancer is the most common type and commonly present in 4th to 5th decade of life. Germ cell ovarian tumor is second most common type and present in 2nd decade of life.