Histopathological study of endoscopic gastric biopsies in dyspeptic patients with special correlation to helicobacter pylori

Abstract

Aims: 1. To identify various pathological lesions in gastric biopsies in patients with dyspeptic symptoms 2. To determine that H. pylori is a major etiologic organism in the pathogenesis of chronic gastritis and to assess the graded variables of Helicobacter associated gastritis. Materials and methods: A total of 93 cases with complaint of dyspepsia were studied during the period July 2016 to July 2017. Endoscopic examinations as well as biopsy specimens from gastric mucosa were studied in all the cases for the various mucosal lesions. Results: Out of 93 cases studied, dyspepsia was most common clinical symptom seen in 80 patients. On endoscopy 18 patients showed normal appearance and erythema was the most common finding in 40 patients. On histopathology, 6 were normal, 80 cases showed various forms of chronic gastritis and 7 cases were malignant. Out of 80 cases of chronic gastritis, 43 showed H. pylori positivity. Most of the H. pylori positive cases were associated with activity and mononuclear inflammatory infiltrate. Conclusion: Prevalence of H. pylori in the present study was 46.2% in patients undergoing upper gastro-intestinal endoscopic biopsies. H. pylori associated gastritis is the predominant type of gastritis. Accurate endoscopic and histopathological examination of gastritis according to the Sydney grading system is a valuable indicator of H. pylori infection.