Histopathological findings in the diagnosis of the stages of kaposi sarcoma; which are more valuable?

Deniz Baycelebi,Levent Yıldız,Ozlem Terzi,Seda Gun

doi:10.7243/2055-091x-8-4

Abstract

Histopathological findings in the diagnosis of the stages of kaposi sarcoma; which are more valuable?

Highlights

The human herpesvirus 8 (HHV-8) virus, a member of the gamma-herpesvirus subfamily, plays an important role in the pathogenesis of Kaposi sarcoma (KS), a type of tumor
The incidences of the studied parameters according to the stages were as follows: Vascular horizontal location, inflammation and erythrocyte extravasation (90%) in the patch stage; erythrocyte extravasation (100%), the “promontory” sign, presence of a hyaline globule and/or hemosiderin (96.6%) in the plaque stage; erythrocyte extravasation (98.8%) and the presence of globules (97.6%) in the nodule stage (Table 2, Figures 1-11)
Our study suggests that horizontal placement of vascular structures, erythrocyte extravasation and the promontory findings are frequently observed and statistically significant in the patch stage, and that searching for their comorbidity may help support the diagnosis of that stage

Summary

Introduction

The human herpesvirus 8 (HHV-8) virus, a member of the gamma-herpesvirus subfamily, plays an important role in the pathogenesis of Kaposi sarcoma (KS), a type of tumor. Different histopathological features are prominent in each of the stages; the stages present different difficulties in the histopathological diagnosis and the differential diagnosis. These difficulties in the differential diagnosis include benign or reactive lesions in the patch stage, or other vascular sarcomas or cutaneous spindle cell tumors in the nodule stage [3,4]. It is important to define valid and reliable histopathological diagnostic features for each stage of KS. Kaposi sarcoma (KS) is a local aggressive angioproliferative tumor with various stages having different histopathological findings. The study aimed to determine the finding or a group of findings which is prominent in different stages of KS and which can effectively identify that stage

Methods

Results

Discussion

Conclusion