HISTOPATHOLOGICAL ANALYSIS OF ENDOMETRIAL BIOPSIES FROM WOMEN WITH ABNORMAL UTERINE BLEEDING

Abstract

Background: Histopathological evaluation of endometrial samples is essential in the diagnosing of abnormal uterine bleeding. The abnormal bleeding can be caused by a wide variety of disorders and it is one of the commonest complaints leading to endometrial sampling. This study was carried out to assess the patterns of endometrial histological findings in women with abnormal uterine bleeding (AUB) and to correlate these findings with clinical features. Materials and Methods: One thousand and nine hundred fifty six patients with diagnosis of abnormal uterine bleeding underwent endometrial sampling in Duhok city during a period extended from January 2013 to December 2014. The slides stained with Hematoxylin and Eosin stain were studied. Results: The predominant endometrial histopathological finding was pregnancy related lesion (Retained products of conception) 403 cases (20.6%) followed by secretory endometrium 363 cases (18.5%). Malignant lesions were more common in patients aged 40 years and more and they were comprised 9 cases (0.4%) of all cases. Endometritis was least finding 29 cases (1.8%) followed by endometrial carcinoma 9 cases (0.4%). Conclusions: Histopathological examination of endometrium should be done in women presenting with abnormal uterine bleeding to rule out neoplastic and non neoplastic specially the retained products of conception hyperplasia and malignant lesions. Around 40% of endometrial biopsy reaveled absence of pathological findings which reflects the high icidence of extrauterine causes of abnormal uterine bleeding. Pregnancy related lesions were the highest among organic findings which highlight the needs for more perinatal care.