Abstract
Experimental induction of gliogenous tumors was made in a total of 135 mice of C3H and C57Black strain by intra-cerebral and -cerebellar inoculation of pellets of methylcholanthrene. Fourty-nine animals were found with tumor development in a period of 135 to 528 days.By histological examinations, the tumors were found to consist of 21 gliomas, 8 mixed glioma and and sarcomas, 18 sarcomas, and 2 unclassified tumors. Histological appearance of experimental gliomas was, in general, characterized by cytological malignancy and their mixed cellular composition. Based upon the grade of anaplasia, and the shape and growth pattern pf the predominant tumor cells, a subclassification was made. They were composed of 10 glioblastomas, 3 oligodendroglioma-like, 3 astrocytoma-like and 2 ependymoma-like tumors. The majority of gliomas, however, includes mixed or transitional features between one histological type and another.Nineteen tumors had developed in the cerebellum. There was no tumor incidence with the histology and the ultrastructure suggestive of those of medulloblastoma in man.Because of the histological malignancy and the frequency of mixed gliomas, no significant data was obtained as to the topographical peculiarities in different histological types of experimental gliomas.Twenty-eight tumors including 14 gliomas, were successfully transplanted. They were capable of subsequent transfer into the subcutis and the brain of the mice of the same strain through a number of generations. By repeated transfer, the transplant came to contain uniform cells with more undifferentiated appearance. In addition, the tumors with mixed cellular composition came to separate into their original component parts.From those observations, it is confirmed that experimental mouse gliomas have peculiarities in their cytological and biological malignancy, mixed cellular composition and their frequency of concomitant neoplastic proliferation of mesenchymal tissue elements.
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