Genetic and phenotypic aspects of the interrelationship between cellular and humoral immune response to sheep erythrocytes in mice

Abstract

The presence of the two types of immune reactivity has been shown earlier: 1st--with prevalence of delayed type hypersensitivity reaction over antibody response (in mice of C57Bl/6 strain), 2nd--with prevalence of antibody responses (in mice of CBA strain). These differences first of all have been displayed in case of using by suboptimal doses of antigen. In the present study the character of local and common immune response in mice of BALB/c, DBA/2, CC57BR, C3H strains and (CBA x C57Bl/6)F1 hybrid on different sheep erythrocyte doses has been investigated. It has been revealed, that DBA/2, BALB/c and CC57BR mice react according to the first type and mice of C3H strain--according to the second. It has been concluded, that the relationship between cellular and humoral immune response depends on the structure of H-2 complex and in F1 hybrid mice any of parents' haplotypes can predominate, depending on phenotypical factors.