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https://doi.org/10.1121/1.4782049
Copy DOIPublication Date: May 1, 2007 | |
Citations: 2 |
Previously developed computer programs for simulating ultrasonic scattering in cells and tissues at the microscopic level [T. E. Doyle and K. H. Warnick, J. Acoust. Soc. Am. 120, 3283 (2006)] have been further refined and tested. The programs model the cells and nuclei in tissues as spherical particles with the use of vector multipole expansions and boundary condition solutions for the scattered fields. In addition, theorems, iteration, and matrix methods are used to solve for multiple scattering both inside and outside the cells. The latest refinements include the development of algorithms for simulating ultrasonic scattering from cells with nuclei arbitrarily located within the cell, and not centered as in previous models. Backscatter spectra have also been acquired for simulated cell clusters of up to several thousand cells. The effects of tissue structure, nucleus size, extracellular elastic properties, and intracellular elastic properties were investigated. The models provide a mechanistic link between measurable parameters in medical ultrasound and histological changes associated with various tissue pathologies. The application of these results to the improvement of ultrasonic tissue characterization and the specificity of various ultrasonic imaging modalities are discussed.
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