Abstract
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.
Highlights
Bacterial and fungal infections remain a major clinical challenge
This led to fluorescence saturation when the surfaces were analyzed by fluorescence microscopy (Fig. 2b1)
Fig. 2c1 shows a representative fluorescence image acquired on a cross section, which is compared to that of control rods immersed in buffer solution
Summary
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. In spite of various preventive methods, such as antibiotic prophylaxis and the use of gloves, drapes, masks, and ultraviolet light during surgery and post-surgical wound care, the implants themselves are still susceptible to developing infections near their surface. This is due to the formation of a biofilm on the implant surface that induces a patient’s immune response at the implant/tissue interface. One approach to conferring bioactive glasses with antimicrobial activity is by doping them with antibacterial agents, such as silver, copper, and titanium; or by loading them with antibiotics These elements are incorporated into the glass during the manufacturing process, and as the glass degrades in vivo, ions of those elements are released at a clinically desirable rate[10]. Can be prepared from metal-based nanomaterials, and the variety of possible surface coatings made from these materials make it even more difficult to assess toxicity[14]
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