Abstract
Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular lesions. We performed comparison study between LBC and conventional Papanicolaou smear about cytological diagnosis using split-sample method in 4522 patients. In 13 cases analyses, which were reported with either AGC or adenocarcinoma by either method, LBC tends to be milder than that by conventional smear, however, the credibility of LBC is considered to be near to that of conventional smear with regard to screening for glandular abnormalities. These results indicate that cervical cancer screening should shift to LBC under the enough experience and appropriate dealing with the cytological diagnosis.
Highlights
Uterine cervical cancer is still the most commonly diagnosed cancer among women worldwide, taking second place only after breast cancer [1–4]
Japan Association of Obstetricians and Gynecologists announced a standardized system of terminology reflected by the Bethesda system (TBS) and the screening of cervical lesions are being performed based on this system
We examined the correlation between conventional smears and liquid-based cytology (LBC) in the cytological diagnosis of the glandular lesion in order to make it clear whether LBC has NILM ASC-US ASC-H AGC LSIL HSIL HSILw/FSFI AIS SCC ADC ADSQ Total
Summary
Uterine cervical cancer is still the most commonly diagnosed cancer among women worldwide, taking second place only after breast cancer [1–4]. Malignant or precancerous lesions of glandular cells in uterine cervix are increasing recently, as reported that the incidence of adenocarcinoma of Japan is 16.8% in 2009, and many studies reported higher mortality rate of cervical adenocarcinoma [7–12]. Japan Association of Obstetricians and Gynecologists announced a standardized system of terminology reflected by the Bethesda system (TBS) and the screening of cervical lesions are being performed based on this system [13]. In this new Japanese system, increasing numbers of facilities come to use LBC, which is a global tendency, despite the premise to use conventional smears for sampling.
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