Histological Assessment of the Oral Soft Tissue Regenerative Capacity of Hyaluronic Acid and Ozonated Oil in Vivo.

Abstract

Aims: The objective of this study is to compare the wound healing potential between two different biomaterials after induced surgical intraoral incisions. Materials and methods: The study was conducted on (12) male New Zealand rabbits, randomly divided into two groups (6 animals per group) according to the healing periods (3rd,7th, and 14th) days. Two incisions were made on the buccal mucosa of each rabbit bilaterally. For the first group, the defects were filled with (PerioKIN Hyaluronic 1%) gel, O3OHEAL-M gel for the second group, applied three times daily, two rabbits were randomly selected each group at the (3rd, 7th, and 14th) days, and biopsies were taken. The biopsy specimens were subjected to histological evaluation to assess the physiological parameters of the wound-healing process. Results: median results of Inflammatory Cells Infiltration grading in which day 3 group II was the highest and day 14 was lowest and Granulation tissue formation in which day 7 was highest and re-epithelization scoring showed highest at day 14, according to the time period and their were no significant differences of Group versus group (within the same day). So, there is very close activity of the two materials in relation to their use in wounds with tissue loss. Conclusions: use of PerioKIN Hyaluronic 1% gel and O3OHEAL-M gel application three times daily for bare wounds give a satisfactory result for better healing and isolation to get rid of the infection in the appropriate time.