Abstract
The aim of this work was to establish the histological and morphometric changes of the structural components of the rat testes after experimental thermal trauma and under condition of correction. Object and methods. The study was performed on 48 sexually mature outbred white male rats following the rules of bioethics. The experimental animals were divided into three groups: intact; with severe thermal trauma; with burn injury and application of xenodermal substrate after early necrectomy of the damaged tissues. Results and discussion. Already on the 7th day after application of xenodermal substrate the processes of reparative regeneration of hemocapillaries is activated, the degree of vascular disorders and damages of the structural components of the testes are decreased, and regenerative processes are activated. The percentage of significantly altered seminiferous tubules is 1.90-fold lower than in animals without correction. In the later stages of the experiment, the usage of the xenodermal substrate contributes to an active flow of regenerative processes and a relative normalization of all the structural components of the testes. Morphometric indicators of mean values of diameter and area of convoluted tubes on the 21th day were significantly (p<0.001) higher by 1.39 times and 2.00 times relative to the indicators in the group of animals without correction. Areas with unchanged histostructure are dominated in the testes at this term. The percentage of significantly altered tubules was 10.58 times lower than the corresponding value in animals with burn injury without correction. Conclusions. Thus, the application of a xenodermal substrate on a wound formed after necrectomy of thermally damaged areas was found to contribute to a significant reduction of vascular disorders and destructive changes of spermatogenic cells. Better state of intracellular components and activation of regeneration contribute to a relative normalization of the testicular structure and morphometric indices in the later terms of the experiment.
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