Abstract
Background:Early detection of oral cancer is of critical importance because survival rates markedly improve when oral lesions are identified at an early stage. Aim of the present study is to investigate the expression of ABO (H) antigens in tissue specimens of oral cancer and potentially malignant disorders and to determine the role of ABO (H) antigens in tumour staging. Materials and Methods:A prospective study was conducted on 60 cases of oral cancer and potentially malignant diseases. Specific red cell adherence test (SRCA-test) was used for studying A, B and O (H) antigens in tissue specimens and iso-antigenicity of epithelium was graded according to degree of adherence of indicator red blood cells. Results:Among OSMF group, grade II adherence was seen in 53.3% cases, grade III in 33.3% cases, grade IV in 13.3% cases. In leukoplakia group, grade II adherence was seen in 26.7% cases, grade III adherence in 53.3% cases, grade IV adherence in 20% cases. Within the leukoplakia group, cases with dysplasia showed decreased adherence, compared with cases without dysplasia. Oral cancer group, negative adherence was seen in 13.3% cases, grade I adherence in 46.7% cases, grade II in 40% cases. In oral cancer group, antigen reactivity was less in poorly and moderately differentiated carcinoma, compared to well differentiated carcinoma. Conclusions:Antigen adherence and degree of loss of ABO (H) antigens in tissue specimens can be used for staging of the tumour.
Highlights
Head and neck cancer is the sixth most common human cancer (Williams, 2000), representing 3% of all types of cancer
Aim of the present study is to investigate the expression of ABO (H) antigens in tissue specimens of oral cancer and potentially malignant disorders and to determine the role of ABO (H) antigens in tumour staging
The mean values for adherence of indicator Red Blood Cells (RBC) in tissue sections were compared among oral benign lesions, leukoplakia, OSMF and oral cancer groups
Summary
Head and neck cancer is the sixth most common human cancer (Williams, 2000), representing 3% of all types of cancer. Detection of cancer is of critical importance because survival rate is markedly improved when the oral cancer is identified at an early stage. Oral cancer often develops clinically as a two stage process, the first step being the appearance of a potentially malignant lesion and the second step is the development of carcinoma. Detection of oral cancer is of critical importance because survival rates markedly improve when oral lesions are identified at an early stage. Aim of the present study is to investigate the expression of ABO (H) antigens in tissue specimens of oral cancer and potentially malignant disorders and to determine the role of ABO (H) antigens in tumour staging. Results: Among OSMF group, grade II adherence was seen in 53.3% cases, grade III in 33.3% cases, grade IV in 13.3% cases. Conclusions: Antigen adherence and degree of loss of ABO (H) antigens in tissue specimens can be used for staging of the tumour
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