Abstract
Objectives To select three study groups consisting of 20 oral squamous cell carcinoma subjects(Group 1), 20 high risk for oral squamous cell carcinoma subjects (Group 2) and 20 healthy controls (Group 3). To collect saliva samples from each subject and analyze for salivary concentration level of glutathione using enzymatic recycling assay and salivary selenium concentration level using atomic absorption spectrophotometry. To analyze data on salivary glutathione and selenium levels in each group and compare findings within and between groups using statistical method of Analysis of Variance (ANOVA) Findings The mean salivary glutathione concentration in healthy control group (5.618±0.5213µM) was higher than the high risk group (5.273± 0.2340µM) and oral cancer group (5.047± 0.5115µM) The difference between groups was statistically significant (p = 0.001). However, the salivary selenium was higher in the oral cancer group (0.0167±0.0083 mg/dl) compared to the high risk (0.0148± 0.0071mg/dl) and healthy control (0.0138± 0.0093 mg/dl) but not statistically significant (p= 0.5414). Conclusion Salivary glutathione level could be a predictor of risk of oral cancer and could therefore serve as a non invasive modality in the early detection of oral cancer.
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