Histo-biochemical analyses of the ameliorative potentials of Phyllanthus nuriri and Carica papaya on some visceral of Albino rats previously treated with Nitrofuratoin

Abstract

Herbal medicine has been used since the days of our forefathers. Nitrofuratoin is a synthetic drug used in the treatment of bacterial infections. This study was aimed at the ameliorative potential of Phyllanthus nuriri and Carica papaya on liver, kidney and lungs histomorphologies of albino rats pre-treated With nitrofuratoin. Twenty eight (28) rats were used for this research work. The research was in two stages. The animals were in five groups in stage one, group 1 with 8 animals received rat pellet and water and was used as control while group 2, 3, 4, and 5 with five rats each received 100 mg/kg body weight of nitrofuratoin. After 14 days of administration, four rats from group the control group (1) and four rats from the test groups were sacrificed, tissues were harvested taken for histological evaluation. In stage two, group 1and 2, received rat pellet and water and served as positive and negative control, group 3, 4,and 5 received 100mg/kgbody weight of Phyllanthus nuriri, Carica papaya and combine extract respectively. After 14 days of administration, Animals used as control experiment and test were weighed, sacrificed via cranial dislocation, and tissues harvested for histopathological evaluation There were significant increase (P < 0.05) in potassium, chloride and bicarbonate and also deleterious effect on the kidney, liver and lungs in nitrofuratoin administered rats. All these physiological and morphological alterations were repaired with P. niruri and C. papaya and combined plant extract. The plant extract could serve as cheap and affordable treatment for kidney, lungs and liver inflammation.