Abstract
Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.
Highlights
Alterations of hippocampal anatomy have consistently been reported in schizophrenia.[1]
We studied 21 schizophrenic patients giving written informed consent with the Positive and Negative Syndrome Scale (PANSS).[4]
The computational model by van Leemput[5] incorporates a prior distribution that makes predictions about where neuroanatomical labels are expected to occur. This prior is based on a generalization of various probabilistic atlases, and is automatically learned from manual segmentations of the hippocampal formation in MRI images
Summary
Alterations of hippocampal anatomy have consistently been reported in schizophrenia.[1]. The role of hippocampal CA subfields volume for positive symptoms has not been investigated in vivo
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