Hippocampal orchestration of associative and sequential memory networks for episodic retrieval

Abstract

Episodic memory involves the recollection of contextual details replayed mentally across time. Here, we propose the association-sequence network (ASN) model, characterizing complementary cortico-hippocampal networks underlying the retrieval of simultaneously associated and sequentially ordered events. Participants viewed objects, presented singly or in pairs, and later reported whether two objects were shown simultaneously, consecutively, or farther apart in time. Behavioral results and hippocampal activation reveal a correlation between the two sequential conditions but not the simultaneous condition, despite the temporal proximity of consecutive pairs. We also find that anterior hippocampal activity is modulated by temporal distance. Distinct cortical networks are engaged during simultaneous and sequential memory (prefrontal cortex and angular gyrus for association; supplementary motor cortex and precuneus for sequence); notably, these regions show differential connectivity with the hippocampus. The ASN model provides a comprehensive framework for how we reconstruct memories that are both rich in associative detail and temporally dynamic in nature.