High-turnover aminopyridine-based Pd-catalysts for Suzuki–Miyaura reaction in aqueous media

Abstract

A high-turnover catalytic system based on commercially available aminopyridines (L) and PdCl2 has been developed for Suzuki–Miyaura reaction in aqueous media. Reactions of arylboronic acids with a wide range of aryl iodides, bromides and chlorides proceeded in the presence of these catalysts for a short time in aqueous media to afford the cross-coupling products in high yields. Furthermore, this protocol allows tolerating a wide range of functional groups.