High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides with an 8-channel electrical titrator

Abstract

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides were performed by employing an automatic 8-channel electrical titrator. Silver nitrate (AgNO3) and sodium tetraphenylborate (NaTPB) were used as titrants. When AgNO3 was used for measuring the drugs in pure form, recoveries were 97.6%–102.0% with RSD values ≤1.0%; for measuring them in pharmaceutical formulations, recoveries were 96.6%–99.1% with RSD values ≤1.0%. Batch samples of eight could be measured simultaneously and maximally 30 measurements per minute could be completed. When NaTPB was used for measuring the drugs in pure form, the recoveries were 96.8%–102.6% with RSD values ≤0.8%; for measuring them in pharmaceutical formulations, the recoveries were 97.5%–102.7% with RSD values ≤0.9%. For all analyses, no auxiliary devices or chemicals were needed and there was no requirement for changing or cleaning working electrodes between measurements. The efficiency, accuracy and precision of the proposed method make it an alternative for routine quality control analyses.