High-tailing it to the apical surface. Focus on “Apical targeting of the P2Y4 receptor is directed by hydrophobic and basic residues in the cytoplasmic tail”

Abstract

epithelial cell function requires the generation and maintenance of polarized apical and basolateral membrane domains with distinct protein and lipid compositions. This asymmetry in membrane composition is essential for myriad cell functions that include substratum adhesion, cell-cell communication