Abstract
Reported is an lateral-mode resonant cantilever sensor that features a much depressed liquid drag force, thereby, achieving a much higher quality factor of 249 in water and higher specific mass sensitivity in liquids, compared with traditional out-of-plane resonant cantilevers. With 8.8Hz/pg sensitivity calibrated by specific binding streptavidin-labled Dynabeads with the biotin-immobilized cantilever in Phosphate Buffered Saline (PBS) solution, specific-antibody immobilized cantilevers have real-time detected E. coli in PBS solution. Real-time detection of Hg2+ ions in aqueous Hg(NO 3 ) 2 is also carried out by using the sensing-group-modified cantilevers, resulting in a finer noise-limited resolution than 100ppb.
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