Highly stable Cs4PbBr6/CsPbBr3perovskite nanoparticles as a new fluorescence nanosensor for selective detection of trace tetracycline in food samples

Abstract

Listen

Translate article

The overuse of antibiotics increases resistant bacteria, and their accumulation in the human body resulting in a pernicious influence or allergic effect on human health. As antibiotics have been used in livestock, their residue in food products is a serious problem. Therefore, the determination of tetracycline (TC) – an antibiotic in food samples by a simple, highly sensitive technique is necessary. This report presents a fluorescence sensor to detect TC based on fluorescence quenching by inner filter effect (IFE) between TC and Cs4PbBr6/CsPbBr3 perovskite material. Cs4PbBr6/CsPbBr3 acts as a fluorescence source with high luminescence quantum yield, narrow emission peak, and short radiative lifetime. It is also protected by perofluorooctyltriethyloxylsilane fluorocarbons assembled on the particle surface to form a water-resistance layer due to the high hydrophobic groups, –CF2– and –CF3, resulting in high aqueous dispersion. Under optimized conditions, the proposed sensor showed high sensitivity and selectivity to detect TC in food samples. The limit of detection is calculated as 76 nM with a linear range of 0.4 – 10 µM. The fluorescence quenching mechanism is assigned to IFE based on the excitation spectrum of Cs4PbBr6/CsPbBr3 and the absorption spectrum of TC, as well as the compensatory fluorescence intensity of Cs4PbBr6/CsPbBr3 with the energy absorbed by TC concentration.