Highly sensitive platform utilizing poly(l-methionine) layered carbon nanotube paste sensor for the determination of voltaren

Abstract

The contemporary study describes the poly(l-methionine) modified carbon nanotube based platform for the enhanced sensitive determination of Voltaren (VTN). The quantitative assessment of this clinically and environmentally important anti-inflammatory drug is of great concern. The distinct voltammetric approaches namely cyclic voltammetry and differential pulse voltammetry were functionalized for the electrochemical investigation of VTN in the solution of phosphate buffer having pH 7.0. The surface features of the proposed electrodes were consummated by Field emission scanning electron microscopy (FE-SEM) and Electron impedance spectroscopy (EIS) data. The fabricated electrode demonstrates enhanced electro-catalytic behaviour towards the redox response of VTN with the diminution of over potential as equated to unmodified electrode. The proposed electrode was successfully used for the selective determination of VTN in the presence of Tryptophan (TRP). The various parameters feigning the enhancement in analytical signal such as number of polymerization cycles, preconcentration time, sweep rate, electrolyte pH were also studied. Under the optimum experimental circumstances VTN presents a linearity in the concentration range of 2 μM to 50 μM and the detection limit was evaluated to be 0.10 μM. The pertinence of the constructed electrode was examined by the analysis of VTN in pharmaceutical formulation.