Highly sensitive plasmonic-grating PCF biosensor for cancer cell detection

Abstract

Highly sensitive biosensor based on D-shaped photonic crystal fiber (PCF) with plasmonic grating is introduced and analyzed. The suggested structure is tested using four different grating structures (rectangular, triangular, circular, or elliptical) on the polished surface of the D-shaped PCF. The sensing operation depends on surface plasmon resonance mechanism where the analyte refractive index (RI) is utilized to control the coupling between the core mode and surface plasmon mode via phase matching phenomenon. Rhodium is employed as a plasmonic material to induce the SPMs. The resonance (i.e., phase matching) wavelength is a function of the analyte RI. The geometrical parameters of the proposed structure are optimized using full vectorial finite element method to enhance the sensor sensitivity. The proposed biosensor can be utilized in the detection of different cancerous Basel, Breast and Cervical cells. The performance of the reported biosensor is investigated in terms of sensitivity, linear response, and fabrication tolerance. The reported biosensor has high sensitivities of 19,750 nm/RIU, 20,428 nm/RIU and 20,041 nm/RIU for the detection of Basel, Breast and Cervical cancer cells, respectively. The presented biosensor is a good candidate for biological sample detection and organic chemical sensing.