Abstract
In order to achieve the on-site rapid detection of trace uranium under excitation with visible light and avoid the harmful effect of toxic organic solvent to human body and organisms, in this work, a novel water-soluble, environmental-friendly and biocompatible aggregation-induced emission (AIE) fluorescence probe was fabricated by introducing the pyridine quaternary ammonium cation and amide group into the propeller structure of triphenylamine (TPA). And by creatively using bovine serum albumin (BSA) in PBS buffer as the sensitizing agent to replace the toxic organic solvent, the probe can emit intense red fluorescence under excitation with visible light (470 nm), exhibiting very low cytotoxicity and great anti-interference ability against large equivalent of different metal ions and anions over wide pH range. After further integration with the self-constructed portable fiber optical sensing system, the satisfying detection limit as low as 7.44 nM (1.77 ppb) can be achieved. The established method has been applied successfully for sensing uranium in complex real samples such as uranium leachate, seawater and cancer cells, demonstrating excellent analytical performance and great potential for in-situ rapid detection and timely evaluation of the uranium contamination in vivo and in field.
Published Version
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