Abstract
Due to the prominent photochemical and photophysical properties, the benzofurazan (NBD) fluorophore is a popular platform for constructing fluorescencet sensors. We reported herein a strategy to tune the fluorescence of NBD by modulating the push-pull pairs on the benzene ring, and obtained two novel fluorescent probes, MeS-DMAB and EtS-DMAB, which can selectively detect hypochlorous acid (HOCl) over other reactive oxygen species in aqueous solution with a large stokes shift (∼170 nm). The synthesis and optical properties of these two probes were described. The reaction products of HOCl with MeS-DMAB were isolated and characterized. It turns out that oxidation of the thioether to the corresponding sulfoxide accounts for the turn-on fluorescence. Finally, the probe EtS-DMAB was successfully applied to image exogenous and endogenous HOCl in live cells.
Published Version
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