Abstract
CMW-1, containing a 3.8 kb Eco RI fragment, was isolated from a flow sorted library cloned in Charon 21A from the Los Alamos National Laboratory (LA15NS02). The 3.8 kb fragment has also been inserted into the Eco RI site of pUC18. D15S24 maps to chromosome 15, region 15pter-q13, using a somatic cell hybrid regional mapping panel. Co-dominant segregation was shown for alleles detected with Eco RI and Taq I in two informative Caucasian families totaling 17 individuals. Coordinate variation using multiple enzymes suggests that CMW-1 detects a variable number of tandem repeats.
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