Abstract

Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G-K (1-5), ganoboninone I (6), ganoderlactone G (7), and (24E)-3,11-dioxolanosta-8,24-dien-26-oic acid (8), were isolated from natural fruiting bodies of Ganoderma cf. hochiminhense. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (1), H (2), and J (4) exhibited antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 17, 16, and 5.1 μM, respectively.

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