Abstract
The selective monoalkylation of glycine tert-butyl ester aldimine Schiff base 3 has been realized in high chemical yield with excellent enantioselectivity under mild liquid–liquid phase-transfer conditions by the use of binaphthyl-derived chiral quaternary ammonium bromides 7 and 8 as catalysts. This achievement demonstrates that 3 can be used as a cost-effective substrate for the preparation of optically active α-alkyl-α-amino acid derivatives by chiral phase-transfer catalysis.
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