Highly Efficient Suzuki Coupling of Aryl Chlorides in a Continuous Flow ­Capillary Microreactor

Abstract

The Suzuki reactions of aryl chlorides containing both electron-donating and electron-withdrawing groups with aryl boronic acid, catalyzed by a simple non-phosphine ligand catalyst system, Pd(OAc) 2 /DABCO, were performed in a continuous capillary microreactor at 50 °C. In the microreactor, the coupling product was obtained mostly in near quantitative yield within a four hour residence time. In contrast, the conversions were only 12-69% in batch reactions.