Abstract
A low temperature polyol process, based on glycolaldehyde mediated partial reduction ofFeCl3·6H2O at120 °C in the presence of sodium acetate as an alkali source and2, 2′-(ethylenedioxy)-bis-(ethylamine) as an electrostatic stabilizer has been usedfor the gram-scale preparation of biocompatible, water-dispersible, aminefunctionalized magnetite nanoparticles (MNPs) with an average diameter of6 ± 0.75 nm. With a reasonably high magnetization (37.8 e.m.u.) and amine groups on theouter surface of the nanoparticles, we demonstrated the magnetic separationand concentration implications of these ultrasmall particles in immunoassay.MRI studies indicated that these nanoparticles had the desired relaxivity forT2 contrast enhancement in vivo. In vitro biocompatibility, cell uptake and MR imagingstudies established that these nanoparticles were safe in clinical dosages and byvirtue of their ultrasmall sizes and positively charged surfaces could be easilyinternalized by cancer cells. All these positive attributes make these functionalnanoparticles a promising platform for further in vitro and in vivo evaluations.
Published Version
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