Abstract
A salivary duct carcinoma (histologically similar to a breast ductal carcinoma) is an uncommon high-grade, aggressive malignant tumor with frequent perineural and lymphovascular invasion. It predominantly occurs in the major salivary glands, especially the parotid gland, and may arise from a preexisting pleomorphic adenoma or de novo. This tumor shows a male predominance and is relatively uncommon in female patients. To the best of our knowledge, this is the first reported case of an ethnic Taiwanese woman with a salivary duct carcinoma. We report a case of 45-year-old woman who presented with chin pain, facial palsy, and double vision, A stony hard mass in the right parotid gland was found on the physical examination. Histopathology of the parotid tumor tissue revealed a cribriform, papillary, or solid growth pattern of neoplastic ductal epithelial cells with comedo-like central necrosis and invasive irregular glands or cords of tumor cells with a desmoplastic reaction, Metastasis of breast ductal carcinoma should be ruled out before diagnosis of a salivary gland carcinoma due to the poor prognosis of high-grade salivary duct carcinomas even with aggressive therapy. According to her clinical history and previous surgical removal of a fibroadenoma of the breast 5 years previous, ductal carcinoma of the breast was ruled out. The patient died of the disease 15 months after the diagnosis due to pulmonary and hepatic metastases.
Published Version
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