Abstract
Purpose The aim of the present cohort study was to explore the longitudinal association between high-sensitivity C-reactive protein (CRP) and hyperuricemia in Chinese population. Furthermore, we conducted subgroup analyses to explore this association according to age, sex, and body mass index. Methods A total of 5,419 healthy participants were enrolled in the final cohort analysis. The high-sensitivity CRP level was measured by immunoturbidimetric assay. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL (416 μmol/L) in men and ≥6.0 mg/dL (357 μmol/L) in women. Multivariate logistic regression was used to analyze the association. Results During the 4 years follow-up, 474 participants developed hyperuricemia. Compared with participants in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted odds ratio (OR) (95% confidence interval [CI]) for incident hyperuricemia in the highest tertile was 1.36 (1.02, 1.82). In the subgroup analyses, high-sensitivity CRP was positively associated with the incidence of hyperuricemia after multivariate adjustments (P for trend = 0.04) in women. Compared with the women in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted OR (95% CI) in the highest tertile was 1.69 (1.10, 2.66). No statistically significant association was found in other subgroups. Conclusions The findings of this prospective cohort study suggest that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese, especially in women.
Highlights
Hyperuricemia, as an important chronic disease, threatens human health due to its association with increased risks of multiple comorbidities and mortality [1, 2]
Compared with the participants in the lowest tertile of C-reactive protein (CRP), those in the highest tertile were more likely to be male (P for trend
We suggested that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese women, while it is a limited indicator for prediction
Summary
Hyperuricemia, as an important chronic disease, threatens human health due to its association with increased risks of multiple comorbidities and mortality [1, 2]. Several previous studies [18,19,20,21,22] had shown that CRP was positively associated with the prevalence of hyperuricemia or the high level of uric acid. While another study [23] has suggested that increased uric acid was not correlated with CRP. The design of previous studies has been limited in determining a causal association between highsensitivity CRP and hyperuricemia. One prospective study [25] included 4154 participants aged ≥55 years from the Rotterdam Study suggested that increased levels of uric acid were associated with higher
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