Abstract
AimTo determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes. MethodsData from a prospective cohort - the Coronary Artery Calcification in Type 1 Diabetes Study - were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4±0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by ≥2.5mm3 or development of clinical coronary artery disease during the follow-up period. ResultsFibrinogen levels were higher in progressors than in non-progressors (276±61mg/dl versus 259±61mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile. ConclusionsHigher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.
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