High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC)

Myrto K Moutafi,Katherine M Bates,Thazin Nwe Aung,Thazin Nwe Aung,Rolando Garcia Milian,Vasiliki Xirou,Vasiliki Xirou,Ioannis A Vathiotis,Niki Gavrielatou,Niki Gavrielatou,Athanasios Angelakis,Athanasios Angelakis,Kurt A Schalper,Leonidas Salichos,David L Rimm

doi:10.1136/jitc-2024-009039

High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC)

Myrto K Moutafi, Katherine M Bates + Show 13 more

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https://doi.org/10.1136/jitc-2024-009039

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Journal: Journal for ImmunoTherapy of Cancer	Publication Date: Jun 1, 2024
Citations: 2	License type: CC BY-NC 4.0

#Tissue Microarray Spots #Non-small Cell Lung Cancer #Immune Checkpoint Inhibitor #Tumor-cell Compartment #Validation Cohort #Cox Proportional-hazards Model Analysis #Arginine Rich Protein #Leukocyte Compartment #Prespecified Frequency #Cytokeratin

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BackgroundDespite the impressive outcomes with immune checkpoint inhibitor (ICI) in non-small cell lung cancer (NSCLC), only a minority of the patients show long-term benefits from ICI. In this study, we...

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High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC)