Abstract
The goal was to develop a light-microscope platform concept, which allows characterization of live cells in microtiter plates or in live-cell slide chambers with a speed, sensitivity and versatility unattainable so far.The goal was achieved by combining several novel technological concepts: a model-based digital control for a voice coil focus drive; scanner technology to follow a continuously moving sample during image acquisition, thus avoiding the usual stop-and-go; fast sectioning capabilities by using slit-scan confocal concepts; motorized dual emission image registration; and integrated environmental control.
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