Abstract
Abstract The goal was to develop a light-microscope platform concept, which allows the structural and functional characterization of live cells in microtiterplates with a speed, sensitivity and versatility unattainable so far. The goal was achieved by combining several novel technological concepts: • using mineral-cast as body material, thus having a 14x better vibration damping than with conventional metal-materials; • employing a model-based digital control for a voice coil focus drive. The drive features an excursion of 10 mm with nanometer resolution and with minimal response times (1 ms for a 1 μm step and • applying galvanometer-scanning technology to follow a continuously moving sample during image acquisition, thus avoiding the usual stop & go; • implementing rapid (millisecond) switching of excitation wavelengths in the wavelength-range from 280 to 680 nm; • automated dual emission image registration and • easy integration of environmental control.
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