High-Throughput Chiral Molecule Determination Based on Multi-Channel Weak Measurement

Lixuan Shi,Chongqi Zhou,Xinhui Xing,Yang Xu,Yonghong He,Zhangyan Li,Tian Guan,Le Liu,Suyi Zhong,Zhen Qiao

doi:10.1109/jphot.2021.3071267

Lixuan Shi, Chongqi Zhou + Show 8 more

Open Access

https://doi.org/10.1109/jphot.2021.3071267

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Abstract

A multi-channel high-throughput chiral molecule determination method based on weak value amplification (WVA) is proposed for the first time. This method can be used for high-throughput and high-precision determination of chiral molecule. Through the design of multi-channel weak measurement system, we realized the real-time, high-throughput, high-sensitivity and high-resolution detection of chiral molecules by selecting proper measurement states. In this work, we have realized a sensitivity of 11.8 nm/° and a resolution of 3.13 × 10-4° for measuring optical rotation. Moreover, the proposed method is successfully applied for detection of lactose content in milk samples. Furthermore, the system has the advantages of simple and robust real-time detection settings, strong stability, high measurement efficiency and good scalability. This method has important significance in clinical diagnosis, food safety and biological system.

Highlights

Chiral molecules are ubiquitous in nature [1]
In terms of Nuclear Magnetic Resonance (NMR), even though it can directly acquire the enantiopurity by employing the properties of chiral selectors which could generate different peak zone and chemical shifts of the NMR spectrum against the chemical circumstance of isomers, it requires the chiral selector with complex system [3], [4]
We built a high-throughput weak measurement system based on weak measurement theory

Summary

Introduction

Chiral molecules are ubiquitous in nature [1]. The chiral enantiomers, which have mirror symmetrical structures and functional groups, exhibit the same chemical and physical properties but for the opposite optical activity. For the first time, we developed a multi-channel chiral sensor based on the weak measurement, which can realize the real-time and high-precision determination of chiral molecules with simple system and achieve the self-reference and high-throughput monitoring of chiral molecular purity. Since the weak measurement system in this work only produces perturbation between the longitudinal optical phase and photon wavelength, and the multi-channel measurement scheme is expanded in the transverse spatial direction, this measurement system has high robustness and can reduce the disturbance in the transverse space This multi-channel sensor can detect the physical properties of the chiral samples as well as qualitatively test the structures of a sample. We realized the real-time, high-throughput, high-sensitivity, and high-resolution detection of chiral molecules by selecting proper measurement states. This method has important significance in clinical diagnosis, food safety and biological system

Methods and Theories

Materials

The Relationship between Phase Difference and Central Wavelength Shift

A: Deionized water

Conclusion and Discussion