Abstract
Background: The modern dietary habit, which is rich in refined carbohydrates and saturated fats, increases the risk of chronic diseases due to the proinflammatory effect of these nutrients. Aim: To evaluate the impact of high sugar-fat diet in the development of metabolic-inflammatory disorders in non-obese animals. Methods: Male Wistar rats were distributed into two groups according to the diet: control and high sugar-fat for 30 weeks. It was analyzed: dietary efficiency; chow, water and caloric intake; metabolic and hormonal profile in plasma and inflammatory cytokines in epididymal adipose tissue. Data were compared by Student’s t test or by Mann-Whitney U test with p α) levels in epidydimal adipose tissue. The urinary protein-creatinine ratio and albuminuria were higher in the HSF group. Conclusion: HSF diet intake is directly involved in the development of metabolic-inflammatory disorders independent of obesity, dissociating the view that increased adiposity is the major risk factor for complications commonly found in obese individuals.
Highlights
The literature suggests that the metabolic syndrome is consequence of adipose tissue-generated molecules which initiates a state of low-grade inflammation, responsible by metabolic, hemodynamic and vascular consequences [1]
HSF diet intake is directly involved in the development of metabolic-inflammatory disorders independent of obesity, dissociating the view that increased adiposity is the major risk factor for complications commonly found in obese individuals
There was no difference in the caloric intake between the groups and the dietary efficiency was decreased in HSF group
Summary
The literature suggests that the metabolic syndrome is consequence of adipose tissue-generated molecules which initiates a state of low-grade inflammation, responsible by metabolic, hemodynamic and vascular consequences [1]. The adipocyte hypertrophy process leads to adipose tissue dysfunction, characterized by deregulation in the adipokines secretion Within this context, there is an increase in the tumoral necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), leptin and resistin levels and a reduction of adiponectin, a protective and anti-inflammatory agent [3] [4]. The modern dietary habit, referred as Western Diet, which is rich in refined carbohydrates, saturated fats, and sweetened beverages [14] could increase the risk of chronic diseases and mortality, and leads to a life quality impairment due to the proinflammatory effect of these nutrients [15]. Methods: Male Wistar rats were distributed into two groups according to the diet: control and high sugar-fat for 30 weeks It was analyzed: dietary efficiency; chow, water and caloric intake; metabolic and hormonal profile in plasma and inflammatory cytokines in epididymal adipose tissue. Conclusion: HSF diet intake is directly involved in the development of metabolic-inflammatory disorders independent of obesity, dissociating the view that increased adiposity is the major risk factor for complications commonly found in obese individuals
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