Abstract
BackgroundHuman HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues. This protein has been found to be associated with some gynecological cancers; as such, this study aimed to investigate blood HTATIP2/TIP30 levels in patients with ovarian cancer.MethodsTwenty-three women with ovarian cancer and 18 patients with various non-cancerous gynecological complaints (for example, dysfunctional uterine bleeding, fibroids, and urinary incontinence) were included in the study. The pathological diagnosis of ovarian cancer was adenocarcinoma. HTATIP2/TIP30 concentration in the patients’ blood samples was determined using ELISA kits.ResultsThe HTATIP2/TIP30 level was significantly higher in the cancer group than in the control group (1.84 ± 0.82 versus 0.57 ± 0.13 ng/ml, mean ± SD).ConclusionsWe demonstrated the potential role of HTATIP2/TIP30 in ovarian cancer for the first time, thereby enlightening future studies targeting HTATIP2/TIP30 in ovarian cancer treatment, diagnosis, and prevention.
Highlights
Human Human immunodeficiency virus (HIV-1) TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues
The aim of our study was to investigate the levels of HTATIP2/TIP30 in serous ovarian cancers, using the enzyme-linked immunosorbent assay (ELISA) method, and to determine whether altered HTATIP2/TIP30 levels correlate with cancer occurrence
Downregulation of HTATIP2/TIP30 has been observed in other cancer types, including melanoma, colon cancer, breast cancer, neuroblastoma, and hepatocellular carcinoma [13,14,16]
Summary
Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues. This protein has been found to be associated with some gynecological cancers; as such, this study aimed to investigate blood HTATIP2/TIP30 levels in patients with ovarian cancer. The onset is often insidious; the symptoms are vague and may mimic other conditions This may lead to a delay in diagnosis, and currently, three-quarters of women with ovarian cancer are diagnosed when the disease has spread throughout the abdomen [3,4]. Many factors affect cell growth and related abnormal tumor growth in ovarian cancer.
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