Abstract
Objectives: Evidence suggests that inflammation and dyslipideamia play a key role in the pathogenesis of coronary artery disease (CAD). High sensitivity C-reactive protein (hs- CRP) is a sensitive marker of inflammation. We attempted to evaluate the contribution of dyslipidaemia and inflammation in CAD.Materials and methods: Three hundred and nine males (103 with myocardial infarction - MI, 103 with established CAD, 103 healthy controls) were studied. The serum hs-CRP, lipids and plasma glucose were determined.Results: Baseline mean hs-CRP levels in patients with established CAD and MI were significantly higher compared to controls (3.4 ± 1.62 VS. 1.70 ± 0.60 mg/L, p = 0.001) (3.7 ± 0.65 VS. 1.70 ± 0.60 mg/L, p = 0.001). A significant negative correlation observed between hs-CRP and HDL-Ch (r = -0.359, p = 0.001).Conclusion: Inflammation (which was reflected by elevated hs-CRP) and dyslipidamia were associated with coronary artery disease.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.44-50
Highlights
Atherosclerosis is clearly multi-factorial, but the role of inflammatory processes in coronary artery disease has been of great interest in recent years
Our study showed that hs-CRP levels both in established coronary artery disease (CAD) group and the STEMI group were significantly higher compared to controls
In conclusion, serum hs-CRP levels were high both in patients with established CAD and ST- elevation myocardial infarction compared to controls
Summary
Atherosclerosis is clearly multi-factorial, but the role of inflammatory processes in coronary artery disease has been of great interest in recent years. The common exclusion criteria were as follows: history of recent surgery or major trauma (within 3 months) or history of acute coronary syndrome in the past 3 months, previous coronary artery bypass graft (CABG), malignancy, chronic inflammatory disorders, current acute severe infections (CRP level more than 10 mg/dL), dementia or any structural damage to the central nervous system, renal dysfunction (was defined as serum creatinine concentration more than 2 mg/dL (177 mmol/L), chronic liver disease and alcohol dependency based on the CAGE19 This clinical protocol was approved by the Ethical Review Committee of Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka and conducted according to the ethical guidelines outlined in the Declaration of Helsinki.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call