High Sensitivity C-Reactive Protein and Cholesterol Level as Risk Markers for Both Periodontitis and Coronary Artery Disease

Abstract

Objectives: The association between periodontal disease and cardiovascular disease (CVD) has received considerable attention, although it is unclear whether there is a causal component. Therefore, this study aimed to determine the Correlation between high sensitivity C reactive protein (hs-CRP) and total blood cholesterol levels in periodontitis (PD) and coronary artery disease (CAD). 
 Methods: Eighty subjects (40 males and 40 females) divided into four equal groups: Group 1: control group, healthy without CAD or PD, group 2: PD without CAD (n=20). group 3: PD with CAD, and group 4: CAD without PD. Periodontitis was defined according to the 2017 periodontal disease classification. Periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded. All participants were assessed for CAD by angiography (coronary computed tomography angiography or coronary angiography). Finally, serum hs-CRP and total cholesterol levels were determined by using the particle enhanced immunoturbidimetric assay method. 
 Results: The median of serum cholesterol and hs-CRP levels was significantly lower in the control group than the patients’ groups (P<0.05). There were no statistically significant differences in gender and age among the studied groups (P>0.05). Furthermore, significant, positive, and strong correlations of PPD and CAL with the hs-CRP and Cholesterol. 
 Conclusions: Serum levels of hs-CRP and Cholesterol were positively proportionate to the measurements of CAL and PPD by increasing the severity of PD parameters (PPD and CAL), serum level of CAD biomarkers (hs-CRP and Cholesterol) were increased.