Abstract
A new sensitive electrochemical sensor has been constructed based on glassy carbon electrode (GCE) modified by nanocomposite of multiwall carbon nanotubes (MWCNTs) and metal–organic frameworks of copper (CuMOFs). The voltammetric response of the offered sensor (CuMOFs-MWCNTs/GCE) exhibited the catalytic effect toward imatinib (IMB). To characterize the structure and morphology of the constructed sensor, the procedures of electrochemical impedance spectroscopy (EIS) and field emission scanning electron microscopy (FE-SEM) were applied. The porosity of CuMOF was described by Brunauer–Emmett–Teller (BET) and Barrett–Joyner–Halenda (BJH) technique. This sensor depicted an excellent electrocatalytic response for IMB detection under optimized conditions of solution pH, scan rate, accumulation potential, and time. Two linear segments in the calibration plot have been obtained for ranges of 0.01–20 and 20–220 µM with the limit of detection (LOD) 4.1 nM. The prepared sensor results were acceptable for the quantitative measurement of IMB in human blood serum (HBS), urine, and pharmaceutical dosage (Tablet), and it compared well with the reported HPLC method.Finally, the fabricated sensor demonstrated an acceptable accuracy, reproducible behaviour, and also, high stability in all electrochemical evaluations. Besides, analytical parameters were determined, and the results were compared with the reportages of similar methods.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
